Cell-cell adhesion mediated by integrin

Across TCGA cell cohorts, RNA activity of the Cell-cell adhesion mediated by integrin pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SDC4, SUMO3, and ICAM1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell-cell adhesion mediated by integrin activity versus SDC4 in BONE (Pearson r = 0.86).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	SDC4 →	+2.794	+0.400	.008	.004	3	8
BONE	SUMO3 →	+0.875	+0.318	.006	.003	3	7
STOMACH	ICAM1 →	+4.234	+0.681	<.001	<.001	3	6
SOFT_TISSUE	NCEH1 →	+2.560	+0.280	.007	.002	2	7
BLOOD_Lymphoma	STX4 →	+0.773	+0.273	<.001	<.001	3	6
OESOPHAGUS	STK10 →	+1.280	+0.395	.002	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033631 vs SDC4 — BONE

Explore this scatter interactively →