Negative regulation of cell adhesion mediated by integrin

Across TCGA cell cohorts, RNA activity of the Negative regulation of cell adhesion mediated by integrin pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POM121L2, FN3K, and ABCA7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, POM121L2 grouped by Negative regulation of cell adhesion mediated by integrin-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	POM121L2 →	-0.040	-1.304	.001	.004	3	3
OVARY	FN3K →	+1.515	+0.924	<.001	<.001	3	3
OVARY	ABCA7 →	+1.230	+1.096	.004	<.001	3	3
SKIN	P4HA3 →	+0.895	+0.620	.002	.009	3	3
LUNG_SCLC	ACVR1 →	+1.028	+0.814	<.001	.009	3	3
LIVER	PRICKLE1 →	+2.684	+0.530	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

POM121L2 by Negative regulation of cell adhesion mediated by integrin activity — URINARY_TRACT

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