Regulation of cell adhesion mediated by integrin

Across TCGA cell cohorts, RNA activity of the Regulation of cell adhesion mediated by integrin pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPN1, GIGYF2, and FBXO34, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPN1 grouped by Regulation of cell adhesion mediated by integrin-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	RPN1 →	+0.927	+1.602	.003	.001	3	4
LUNG_SCLC	GIGYF2 →	-0.623	-0.859	.001	.001	3	4
BLOOD_Myeloma	FBXO34 →	+0.666	+1.059	.009	.002	2	4
BLOOD_Myeloma	CLDN9 →	+1.504	+1.315	.003	.003	3	3
BLOOD_Myeloma	TNFRSF12A →	+2.268	+1.360	.002	.003	3	3
BLOOD_Leukemia	FUCA1 →	+2.238	+1.335	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPN1 by Regulation of cell adhesion mediated by integrin activity — BONE

Explore this box plot interactively →