Regulation of cell adhesion mediated by integrin

Across TCGA cell cohorts, RNA activity of the Regulation of cell adhesion mediated by integrin pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP8B2, H4C5, and MBOAT2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell adhesion mediated by integrin activity versus ATP8B2 in OESOPHAGUS (Pearson r = -0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ATP8B2 →	-2.494	-1.457	<.001	.002	3	4
BREAST	H4C5 →	-0.896	-0.733	.003	.007	3	4
BONE	MBOAT2 →	+1.506	+1.753	.004	.003	3	4
LUNG_SCLC	FOXD4 →	+0.770	+1.138	.008	.001	3	4
BLOOD_Leukemia	PTK7 →	+2.596	+1.173	<.001	<.001	3	4
LUNG_NSCLC_LUAD	MRAS →	-1.458	-0.947	.003	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033628 vs ATP8B2 — OESOPHAGUS

Explore this scatter interactively →