Cell adhesion mediated by integrin

Across TCGA patient cohorts, RNA activity of the Cell adhesion mediated by integrin pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ANTXR2, COL6A1, and COL6A2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell adhesion mediated by integrin activity versus ANTXR2 in UCEC (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ANTXR2 →	+0.529	+0.217	<.001	<.001	3	9
COAD	COL6A1 →	+0.632	+0.321	<.001	<.001	3	8
GBM	COL6A2 →	+0.950	+0.231	<.001	<.001	3	8
OV	PPP1R18_S224 →	+0.846	+0.243	<.001	<.001	3	8
OV	SERPINF1 →	+0.801	+0.277	<.001	<.001	3	7
LSCC	SF3B2 →	-0.290	-0.302	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033627 vs ANTXR2 — UCEC

Explore this scatter interactively →