Cell adhesion mediated by integrin

Across TCGA cell cohorts, RNA activity of the Cell adhesion mediated by integrin pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGAV, PKN2, and TBC1D3H, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ITGAV grouped by Cell adhesion mediated by integrin-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	ITGAV →	-0.650	-1.999	<.001	<.001	3	7
BREAST	PKN2 →	-0.211	-0.479	<.001	.008	2	6
BLOOD_Myeloma	TBC1D3H →	-0.330	-1.966	<.001	<.001	3	4
BLOOD_Myeloma	HNF4G →	-0.317	-1.630	.007	.003	3	4
BONE	ITGB4 →	-0.291	-1.081	.002	.006	3	4
BONE	SOX11 →	+0.222	+1.488	.009	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ITGAV by Cell adhesion mediated by integrin activity — BLOOD_Myeloma

Explore this box plot interactively →