Cell adhesion mediated by integrin

Across TCGA cell cohorts, RNA activity of the Cell adhesion mediated by integrin pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDKN2AIP, MYBL1, and NUP62, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDKN2AIP grouped by Cell adhesion mediated by integrin-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CDKN2AIP →	+0.790	+1.291	.003	.003	3	5
BONE	MYBL1 →	+2.068	+1.704	.002	.001	3	4
BONE	NUP62 →	+0.895	+1.214	.004	.007	3	4
OESOPHAGUS	SPATA5 →	+0.555	+1.194	.002	<.001	2	5
BLOOD_Leukemia	SLC4A7 →	+1.425	+1.246	<.001	<.001	3	4
LUNG_NSCLC_LUAD	ATP5PF →	+0.373	+0.632	.007	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDKN2AIP by Cell adhesion mediated by integrin activity — BLOOD_Leukemia

Explore this box plot interactively →