Cell adhesion mediated by integrin

Across TCGA cell cohorts, RNA activity of the Cell adhesion mediated by integrin pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP3R2, MCOLN3, and TOMM5, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPP3R2 grouped by Cell adhesion mediated by integrin-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PPP3R2 →	+0.238	+0.156	.004	.008	3	7
LUNG_SCLC	MCOLN3 →	-0.315	-0.166	.001	.005	3	5
BREAST	TOMM5 →	-0.159	-0.142	.003	.004	3	5
LARGE_INTESTINE	B4GALT2 →	+0.313	+0.135	<.001	.002	3	4
LARGE_INTESTINE	LSM1 →	-0.202	-0.131	<.001	<.001	3	4
LARGE_INTESTINE	ZNF551 →	+0.124	+0.076	.006	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPP3R2 by Cell adhesion mediated by integrin activity — LUNG_SCLC

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