Positive regulation of integrin activation

Across TCGA cell cohorts, RNA activity of the Positive regulation of integrin activation pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAP1B, TLN1, and FERMT2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAP1B grouped by Positive regulation of integrin activation-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	RAP1B →	-0.263	-1.566	<.001	<.001	3	8
LUNG_NSCLC_LUAD	TLN1 →	-0.444	-1.402	<.001	<.001	3	8
CNS	FERMT2 →	-0.633	-1.401	.002	.002	3	6
BLOOD_Myeloma	ULK1 →	+0.323	+1.226	.001	.008	3	5
BONE	KIF20A →	-0.290	-1.529	<.001	.001	3	5
STOMACH	SP4 →	-0.107	-0.971	.003	.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAP1B by Positive regulation of integrin activation activity — LIVER

Explore this box plot interactively →