Positive regulation of integrin activation

Across TCGA cell cohorts, RNA activity of the Positive regulation of integrin activation pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSPAN4, TTC9, and AP3B1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TSPAN4 grouped by Positive regulation of integrin activation-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TSPAN4 →	+2.983	+1.889	.004	<.001	3	6
URINARY_TRACT	TTC9 →	-2.310	-1.618	.006	.006	3	5
CNS	AP3B1 →	+0.362	+0.813	.005	.002	3	5
CNS	TBX6 →	-0.357	-0.718	.002	.001	3	5
CNS	ARSK →	+0.604	+0.816	.002	.004	3	5
CNS	HEXB →	+1.185	+1.034	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TSPAN4 by Positive regulation of integrin activation activity — URINARY_TRACT

Explore this box plot interactively →