Positive regulation of integrin activation

Across TCGA cell cohorts, RNA activity of the Positive regulation of integrin activation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RECQL, CIP2A, and MCM2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of integrin activation activity versus RECQL in STOMACH (Pearson r = -0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	RECQL →	-1.465	-1.527	<.001	<.001	3	4
STOMACH	CIP2A →	-1.261	-1.527	<.001	<.001	3	4
STOMACH	MCM2 →	-0.641	-1.549	.003	<.001	3	4
BREAST	SMDT1 →	+0.713	+0.852	<.001	.005	3	4
PANCREAS	INPP5E →	-0.621	-1.093	.008	.009	3	4
PANCREAS	NAT1 →	+1.328	+1.674	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033625 vs RECQL — STOMACH

Explore this scatter interactively →