Regulation of integrin activation

Across TCGA patient cohorts, RNA activity of the Regulation of integrin activation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DIPK2B, ESAM, and ECSCR, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of integrin activation activity versus DIPK2B in BRCA (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DIPK2B →	+0.824	+0.731	<.001	<.001	3	7
BRCA	ESAM →	+0.718	+0.768	<.001	<.001	3	6
CCRCC	ECSCR →	+0.808	+0.530	<.001	<.001	3	6
BRCA	ITM2A →	+1.101	+0.583	<.001	<.001	3	6
CCRCC	AOC3 →	+0.984	+0.450	<.001	.004	3	6
BRCA	CNRIP1 →	+0.905	+0.822	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033623 vs DIPK2B — BRCA

Explore this scatter interactively →