Regulation of integrin activation

Across TCGA cell cohorts, RNA activity of the Regulation of integrin activation pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PICALM, CHST5, and PRR16, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PICALM grouped by Regulation of integrin activation-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PICALM →	+0.590	+0.864	.001	.003	3	6
OVARY	CHST5 →	-0.213	-1.059	.001	<.001	3	4
CNS	PRR16 →	+1.736	+0.540	<.001	.006	3	4
SOFT_TISSUE	TPM1 →	+2.665	+0.844	.001	.004	3	4
SOFT_TISSUE	FRMD4A →	+2.730	+0.864	.001	.003	3	4
OESOPHAGUS	FBXO15 →	-0.771	-1.236	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PICALM by Regulation of integrin activation activity — SOFT_TISSUE

Explore this box plot interactively →