Regulation of integrin activation

Across TCGA cell cohorts, RNA activity of the Regulation of integrin activation pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ENC1, BCL6B, and FOXS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ENC1 grouped by Regulation of integrin activation-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ENC1 →	+0.201	+1.023	.008	.002	3	4
LARGE_INTESTINE	BCL6B →	-0.125	-1.122	<.001	<.001	3	4
KIDNEY	FOXS1 →	+0.158	+1.618	.001	.001	3	4
SOFT_TISSUE	SSTR4 →	-0.536	-1.728	.006	<.001	3	4
SOFT_TISSUE	HSPE1 →	+0.949	+1.661	.002	<.001	3	3
SKIN	FOCAD →	+0.232	+1.067	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ENC1 by Regulation of integrin activation activity — LUNG_SCLC

Explore this box plot interactively →