Integrin activation

Across TCGA patient cohorts, RNA activity of the Integrin activation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYL9, AOC3, and DDR2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Integrin activation activity versus MYL9 in UCEC (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MYL9 →	+1.317	+0.752	<.001	<.001	3	9
OV	AOC3 →	+1.302	+0.830	<.001	<.001	3	9
OV	DDR2 →	+1.030	+0.640	<.001	<.001	3	9
OV	ZCCHC24 →	+0.990	+0.776	<.001	<.001	3	9
BRCA	VSTM4 →	+1.026	+0.883	<.001	<.001	3	9
OV	MFAP4 →	+2.336	+1.158	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033622 vs MYL9 — UCEC

Explore this scatter interactively →