Integrin activation

Across TCGA cell cohorts, RNA activity of the Integrin activation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COL6A2, TIAM2, and CCN2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, COL6A2 grouped by Integrin activation-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	COL6A2 →	+4.174	+0.413	<.001	.001	2	5
OESOPHAGUS	TIAM2 →	+0.753	+1.062	.002	.005	3	4
BONE	CCN2 →	+5.974	+1.742	<.001	<.001	3	4
BONE	P3H2 →	+2.675	+1.739	.004	.002	3	4
BONE	LETM2 →	+1.671	+1.742	<.001	<.001	3	4
BONE	BCAP29 →	+1.032	+1.728	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

COL6A2 by Integrin activation activity — LUNG_SCLC

Explore this box plot interactively →