Integrin activation

Across TCGA cell cohorts, RNA activity of the Integrin activation pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FN1, FERMT2, and CALD1, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Integrin activation activity versus FN1 in SOFT_TISSUE (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	FN1 →	+5.250	+0.110	<.001	.001	3	13
BONE	FERMT2 →	+2.503	+0.264	<.001	<.001	3	12
BREAST	CALD1 →	+3.616	+0.175	<.001	<.001	3	11
LIVER	TGFB1I1 →	+4.453	+0.180	<.001	.001	3	11
LIVER	FSTL1 →	+4.546	+0.153	<.001	.002	3	10
LIVER	COL6A2 →	+4.212	+0.194	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033622 vs FN1 — SOFT_TISSUE

Explore this scatter interactively →