Mitochondrial cytochrome c oxidase assembly

Across TCGA patient cohorts, RNA activity of the Mitochondrial cytochrome c oxidase assembly pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CKAP4_S26, TYMP, and SND1_S645, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial cytochrome c oxidase assembly activity versus CKAP4_S26 in PDAC (Pearson r = -0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CKAP4_S26 →	-0.496	-0.029	<.001	<.001	3	8
OV	TYMP →	-0.559	-0.036	.002	<.001	3	7
CCRCC	SND1_S645 →	-0.963	-0.046	<.001	<.001	3	6
GBM	CCDC88B →	-0.352	-0.041	.001	<.001	3	6
CCRCC	CDC42BPB →	+0.173	+0.023	<.001	<.001	3	5
CCRCC	RETREG3_S26 →	-0.425	-0.021	.001	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033617 vs CKAP4_S26 — PDAC

Explore this scatter interactively →