Mitochondrial cytochrome c oxidase assembly

Across TCGA patient cohorts, RNA activity of the Mitochondrial cytochrome c oxidase assembly pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SH2B3, GPR182, and CNRIP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial cytochrome c oxidase assembly activity versus SH2B3 in COAD (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SH2B3 →	-0.612	-0.306	<.001	<.001	3	5
OV	GPR182 →	-0.102	-0.139	<.001	.002	3	4
UCEC	CNRIP1 →	-0.698	-0.169	.001	.005	3	4
LUAD	CD28 →	-0.396	-0.101	.003	.003	3	4
UCEC	ANXA5 →	-0.752	-0.307	<.001	<.001	3	4
UCEC	DDR2 →	-0.601	-0.145	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033617 vs SH2B3 — COAD

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