Mitochondrial cytochrome c oxidase assembly

Across TCGA patient cohorts, RNA activity of the Mitochondrial cytochrome c oxidase assembly pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMIM20, IMMT, and COX4I1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial cytochrome c oxidase assembly activity versus SMIM20 in CCRCC (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SMIM20 →	+0.342	+0.169	<.001	.002	3	7
CCRCC	IMMT →	+0.318	+0.248	<.001	<.001	3	7
UCEC	COX4I1 →	+0.496	+0.213	<.001	<.001	3	7
UCEC	SAMM50 →	+0.406	+0.204	<.001	<.001	3	6
UCEC	SLC25A3 →	+0.477	+0.176	<.001	<.001	3	6
UCEC	ATP5PD →	+0.718	+0.237	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033617 vs SMIM20 — CCRCC

Explore this scatter interactively →