Mitochondrial proton-transporting ATP synthase complex assembly

Across TCGA patient cohorts, RNA activity of the Mitochondrial proton-transporting ATP synthase complex assembly pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CHD3, ALKBH5, and LLGL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial proton-transporting ATP synthase complex assembly activity versus CHD3 in LSCC (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CHD3 →	+0.445	+0.062	<.001	<.001	3	5
LSCC	ALKBH5 →	+0.253	+0.038	<.001	<.001	3	4
LSCC	LLGL1 →	+0.271	+0.050	<.001	<.001	3	4
LSCC	SHMT1 →	+0.546	+0.060	<.001	<.001	3	4
COAD	ST6GAL1 →	-0.450	-0.032	.003	.002	3	4
COAD	AGL →	+0.146	+0.029	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033615 vs CHD3 — LSCC

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