Mitochondrial proton-transporting ATP synthase complex assembly

Across TCGA patient cohorts, RNA activity of the Mitochondrial proton-transporting ATP synthase complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LINC01144, IKBKE, and MINCR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial proton-transporting ATP synthase complex assembly activity versus LINC01144 in OV (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	LINC01144 →	+0.575	+0.148	.004	<.001	3	5
CCRCC	IKBKE →	-0.551	-0.186	.008	<.001	3	5
BRCA	MINCR →	+0.664	+0.218	<.001	<.001	3	5
CCRCC	OGFRL1 →	-0.275	-0.102	.008	.005	3	5
CCRCC	TENM3 →	-0.807	-0.146	.003	<.001	3	5
UCEC	PPAN →	+0.424	+0.172	.007	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033615 vs LINC01144 — OV

Explore this scatter interactively →