Positive regulation of catecholamine secretion

Across TCGA patient cohorts, RNA activity of the Positive regulation of catecholamine secretion pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARL6IP4_S239, AMER1_S868, and KCTD6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of catecholamine secretion activity versus ARL6IP4_S239 in COAD (Pearson r = 0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ARL6IP4_S239 →	+0.271	+0.046	.003	.002	3	4
BRCA	AMER1_S868 →	-1.065	-0.069	.007	.001	3	4
BRCA	KCTD6 →	+0.411	+0.046	<.001	<.001	3	4
OV	LRRFIP1_S714 →	+0.799	+0.060	.003	.009	3	3
LUAD	SF3B1_T244 →	-0.642	-0.102	<.001	<.001	3	3
BRCA	SLK →	+0.220	+0.041	.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033605 vs ARL6IP4_S239 — COAD

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