Negative regulation of catecholamine secretion

Across TCGA patient cohorts, RNA activity of the Negative regulation of catecholamine secretion pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HSP90AB1_S445, SORBS3, and CROCC, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of catecholamine secretion activity versus HSP90AB1_S445 in CCRCC (Pearson r = -0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	HSP90AB1_S445 →	-0.258	-0.072	.001	.002	3	7
BRCA	SORBS3 →	+0.431	+0.074	<.001	<.001	3	6
UCEC	CROCC →	+0.525	+0.105	<.001	<.001	3	6
BRCA	CDC20_T70 →	-0.944	-0.078	.001	<.001	3	6
HNSC	EEF1D →	-0.207	-0.083	.008	.003	3	6
BRCA	ADRA2A_S346 →	+1.744	+0.123	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033604 vs HSP90AB1_S445 — CCRCC

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