Negative regulation of catecholamine secretion

Across TCGA patient cohorts, RNA activity of the Negative regulation of catecholamine secretion pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUP85, BRIP1, and PTPN2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of catecholamine secretion activity versus NUP85 in BRCA (Pearson r = -0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NUP85 →	-0.406	-0.578	.001	.001	3	5
UCEC	BRIP1 →	-0.549	-0.827	.008	<.001	3	5
LSCC	PTPN2 →	-0.355	-0.366	<.001	<.001	3	5
BRCA	CHGA →	+1.896	+0.632	.002	.003	3	4
BRCA	CCL7 →	-1.081	-0.734	.003	<.001	2	5
BRCA	ZNF835 →	+0.402	+0.505	.005	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033604 vs NUP85 — BRCA

Explore this scatter interactively →