Negative regulation of catecholamine secretion

Across TCGA cell cohorts, RNA activity of the Negative regulation of catecholamine secretion pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM244, CASTOR2, and KLHL13, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMEM244 grouped by Negative regulation of catecholamine secretion-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TMEM244 →	+0.338	+1.718	<.001	<.001	3	1
LUNG_SCLC	CASTOR2 →	+0.110	+1.718	.009	<.001	3	1
LUNG_SCLC	KLHL13 →	+0.400	+1.718	.003	<.001	3	1
LUNG_SCLC	MRPL43 →	+0.210	+1.583	.002	.004	3	1
LUNG_SCLC	SPATA20 →	+0.208	+1.718	<.001	<.001	3	1
LUNG_SCLC	GAA →	+0.336	+1.762	.003	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMEM244 by Negative regulation of catecholamine secretion activity — LUNG_SCLC

Explore this box plot interactively →