Negative regulation of dopamine secretion

Across TCGA cell cohorts, RNA activity of the Negative regulation of dopamine secretion pathway is significantly associated with the drug response of multiple features, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are Flavopiridol, Vismodegib, and CCT007093, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, Flavopiridol grouped by Negative regulation of dopamine secretion-low versus -high activity in LUNG_SCLC.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Flavopiridol →	-0.446	-1.404	.001	.029	3	1
LUNG_SCLC	Vismodegib →	+0.399	+1.045	.007	.021	2	1
LUNG_SCLC	CCT007093 →	+0.263	+1.265	.037	.045	2	1
LUNG_SCLC	OF-1 →	-0.494	-1.735	.017	.021	2	1
LUNG_SCLC	VX-11e →	-0.780	-1.228	.042	.044	1	1
LUNG_SCLC	MPS-1-IN-1 →	+0.805	+1.216	.044	.022	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Flavopiridol by Negative regulation of dopamine secretion activity — LUNG_SCLC

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