Regulation of mammary gland epithelial cell proliferation

Across TCGA patient cohorts, RNA activity of the Regulation of mammary gland epithelial cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLRD1, STAT4, and ADGRG3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mammary gland epithelial cell proliferation activity versus KLRD1 in BRCA (Pearson r = -0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	KLRD1 →	-0.307	-0.689	.009	<.001	3	4
COAD	STAT4 →	-0.426	-0.301	.004	.005	3	3
GBM	ADGRG3 →	-0.619	-0.624	<.001	.006	2	4
COAD	ARRDC5 →	-0.173	-0.388	.002	.007	3	3
COAD	RNU6-36P →	-0.545	-0.322	.003	.001	3	3
COAD	LCP2 →	-0.511	-0.276	.005	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033599 vs KLRD1 — BRCA

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