Regulation of mammary gland epithelial cell proliferation

Across TCGA cell cohorts, RNA activity of the Regulation of mammary gland epithelial cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA9, KDM5B, and GEMIN8, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ANXA9 grouped by Regulation of mammary gland epithelial cell proliferation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ANXA9 →	+2.591	+0.559	<.001	<.001	3	5
CNS	KDM5B →	+0.768	+0.627	.002	.001	3	4
CNS	GEMIN8 →	+0.667	+0.796	<.001	<.001	3	4
BLOOD_Leukemia	IRS2 →	-1.336	-1.153	.004	<.001	2	5
BREAST	KLF5 →	-1.268	-0.450	<.001	.001	3	4
BREAST	SEC16A →	+1.387	+0.723	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ANXA9 by Regulation of mammary gland epithelial cell proliferation activity — BREAST

Explore this box plot interactively →