Regulation of mammary gland epithelial cell proliferation

Across TCGA cell cohorts, RNA activity of the Regulation of mammary gland epithelial cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LIF, AHNAK2, and EPB41L5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mammary gland epithelial cell proliferation activity versus LIF in LIVER (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	LIF →	+3.742	+0.384	.001	.004	3	6
OESOPHAGUS	AHNAK2 →	+2.138	+0.160	.003	.009	3	6
BLOOD_Leukemia	EPB41L5 →	-1.393	-0.305	<.001	<.001	3	6
BLOOD_Leukemia	GRN →	+1.174	+0.184	.008	.005	3	5
URINARY_TRACT	LRP12 →	+2.713	+0.292	.006	.002	3	5
BONE	TWF2 →	+1.094	+0.371	.003	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033599 vs LIF — LIVER

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