Response to L-ascorbic acid

Across TCGA patient cohorts, RNA activity of the Response to L-ascorbic acid pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VCL_Y822, TPX2, and CYB5R1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to L-ascorbic acid activity versus VCL_Y822 in CCRCC (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	VCL_Y822 →	+0.600	+0.076	<.001	.001	3	6
BRCA	TPX2 →	-0.801	-0.073	<.001	<.001	3	6
UCEC	CYB5R1 →	+0.682	+0.133	<.001	.002	3	6
LSCC	STRBP →	-0.686	-0.118	<.001	<.001	3	6
BRCA	VRK3_S136 →	-0.555	-0.072	.008	.002	2	7
UCEC	DOCK1 →	+0.324	+0.132	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033591 vs VCL_Y822 — CCRCC

Explore this scatter interactively →