Response to L-ascorbic acid

Across TCGA cell cohorts, RNA activity of the Response to L-ascorbic acid pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGA2, CAT, and ABCA3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to L-ascorbic acid activity versus ITGA2 in STOMACH (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ITGA2 →	+3.812	+0.567	<.001	<.001	3	6
BLOOD_Lymphoma	CAT →	+0.796	+0.213	.004	.009	2	7
STOMACH	ABCA3 →	-2.827	-0.401	<.001	<.001	3	5
BONE	UQCRHL →	-0.735	-0.289	.004	.008	3	5
LUNG_NSCLC_LUSC	COX7C →	-0.766	-0.208	.005	.002	3	5
STOMACH	IER3 →	+5.103	+0.568	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033591 vs ITGA2 — STOMACH

Explore this scatter interactively →