Response to testosterone

Across TCGA patient cohorts, RNA activity of the Response to testosterone pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ENAH_S531, ACIN1_S729, and TNKS1BP1_S178, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to testosterone activity versus ENAH_S531 in UCEC (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ENAH_S531 →	+1.038	+0.064	.001	.007	3	4
BRCA	ACIN1_S729 →	-0.521	-0.028	.001	<.001	2	5
BRCA	TNKS1BP1_S178 →	+0.511	+0.027	<.001	.002	3	4
BRCA	CDH3 →	+0.518	+0.028	.005	.002	3	4
BRCA	EGFR →	+0.531	+0.033	<.001	<.001	3	4
BRCA	KANK3_S160 →	-0.731	-0.038	.007	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033574 vs ENAH_S531 — UCEC

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