Response to testosterone

Across TCGA patient cohorts, RNA activity of the Response to testosterone pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPP1, AQP9, and TREM1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to testosterone activity versus SPP1 in HNSC (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SPP1 →	+2.060	+0.451	.001	.004	3	8
COAD	AQP9 →	+1.043	+0.537	.006	.008	3	7
HNSC	TREM1 →	+0.921	+0.480	.001	.001	3	6
LUAD	SLC2A1 →	+1.364	+0.340	<.001	<.001	3	6
PDAC	DNASE1L3 →	-0.771	-0.279	<.001	<.001	3	6
LUAD	CAVIN2 →	-1.049	-0.314	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033574 vs SPP1 — HNSC

Explore this scatter interactively →