Response to testosterone

Across TCGA cell cohorts, RNA activity of the Response to testosterone pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNTNAP1, FMNL3, and REEP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CNTNAP1 grouped by Response to testosterone-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CNTNAP1 →	-1.492	-1.178	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	FMNL3 →	-1.408	-1.458	.001	.001	3	5
OESOPHAGUS	REEP2 →	-2.058	-1.210	.005	.004	3	5
LARGE_INTESTINE	BRSK1 →	-0.953	-0.769	.001	<.001	3	5
OESOPHAGUS	DNAJB5 →	-1.146	-1.176	.006	.004	3	5
LUNG_SCLC	TMEM251 →	-0.714	-1.670	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CNTNAP1 by Response to testosterone activity — BREAST

Explore this box plot interactively →