Response to testosterone

Across TCGA cell cohorts, RNA activity of the Response to testosterone pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GGCT, ZNF138, and HSPE1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to testosterone activity versus GGCT in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	GGCT →	+1.332	+0.335	.008	.001	3	6
KIDNEY	ZNF138 →	+0.883	+0.250	.005	.003	3	6
STOMACH	HSPE1 →	+1.017	+0.314	.005	<.001	3	6
BLOOD_Myeloma	EXOSC7 →	+0.638	+0.263	.003	.003	3	5
BLOOD_Leukemia	TMEM86A →	-0.611	-0.116	<.001	<.001	3	5
BREAST	NDUFB3 →	+0.712	+0.279	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033574 vs GGCT — UPPER_AERODIGESTIVE_TRACT

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