Transferrin transport

Across TCGA patient cohorts, RNA activity of the Transferrin transport pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAE1, AURKAP2, and TLK2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transferrin transport activity versus RAE1 in LSCC (Pearson r = -0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RAE1 →	-0.539	-0.107	<.001	.007	3	3
OV	AURKAP2 →	+0.779	+0.153	.001	<.001	3	3
BRCA	TLK2 →	-0.331	-0.107	.005	.007	3	3
BRCA	PSTK →	-0.377	-0.155	.002	.001	3	3
UCEC	DNAJC2 →	-0.291	-0.211	.001	.001	3	3
UCEC	ATAD2 →	-0.864	-0.246	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033572 vs RAE1 — LSCC

Explore this scatter interactively →