Transferrin transport

Across TCGA cell cohorts, RNA activity of the Transferrin transport pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GSK3A, CEP68, and HDAC3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GSK3A grouped by Transferrin transport-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	GSK3A →	-0.511	-0.306	.008	.009	3	6
STOMACH	CEP68 →	-0.796	-0.330	.003	<.001	3	5
LIVER	HDAC3 →	-0.577	-0.228	.004	.004	3	5
CNS	GOSR2 →	-0.515	-0.668	<.001	.005	3	5
LARGE_INTESTINE	MXRA7 →	-1.772	-0.163	.003	.007	2	6
BLOOD_Lymphoma	HIGD1A →	+1.006	+0.288	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GSK3A by Transferrin transport activity — SOFT_TISSUE

Explore this box plot interactively →