Transferrin transport

Across TCGA cell cohorts, RNA activity of the Transferrin transport pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are B2M, HLA-C, and HLA-A, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transferrin transport activity versus B2M in LARGE_INTESTINE (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	B2M →	+2.017	+0.247	<.001	<.001	3	8
PANCREAS	HLA-C →	+2.115	+0.262	.002	.005	3	6
STOMACH	HLA-A →	+1.544	+0.239	.002	<.001	3	6
BREAST	DNM2 →	+0.926	+0.241	<.001	<.001	3	6
URINARY_TRACT	PPP1R18 →	+1.357	+0.192	.006	.001	3	6
OESOPHAGUS	TAF1A →	-0.712	-0.187	.003	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033572 vs B2M — LARGE_INTESTINE

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