Anterior/posterior axon guidance

Across TCGA patient cohorts, RNA activity of the Anterior/posterior axon guidance pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GBP1, GBP5, and STAT1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Anterior/posterior axon guidance activity versus GBP1 in UCEC (Pearson r = -0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GBP1 →	-0.649	-0.228	<.001	.002	3	7
COAD	GBP5 →	-0.650	-0.058	.002	.001	3	7
UCEC	STAT1 →	-0.481	-0.214	<.001	.004	3	6
PDAC	EOMES_S596 →	-0.703	-0.088	<.001	<.001	3	5
UCEC	APOL3 →	-0.559	-0.212	<.001	.005	3	5
LSCC	WARS1 →	-0.575	-0.134	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033564 vs GBP1 — UCEC

Explore this scatter interactively →