Anterior/posterior axon guidance

Across TCGA cell cohorts, RNA activity of the Anterior/posterior axon guidance pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GXYLT2, CCDC78, and FRAT2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GXYLT2 grouped by Anterior/posterior axon guidance-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GXYLT2 →	+1.508	+1.238	<.001	<.001	3	4
LUNG_NSCLC_LUSC	CCDC78 →	+1.556	+1.795	.004	.001	3	4
LARGE_INTESTINE	FRAT2 →	-1.210	-0.990	.001	.005	3	4
LUNG_NSCLC_LUAD	TNS4 →	-2.297	-0.858	<.001	.003	3	3
BLOOD_Leukemia	SURF2 →	+0.794	+1.282	.006	.001	3	3
BLOOD_Leukemia	ZBTB7B →	-1.510	-1.161	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GXYLT2 by Anterior/posterior axon guidance activity — LARGE_INTESTINE

Explore this box plot interactively →