Unsaturated fatty acid metabolic process

Across TCGA patient cohorts, RNA activity of the Unsaturated fatty acid metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AKR1C3, SF3B1, and POLR2B, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Unsaturated fatty acid metabolic process activity versus AKR1C3 in UCEC (Pearson r = 0.50).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AKR1C3 →	+1.414	+0.053	<.001	<.001	3	8
GBM	SF3B1 →	-0.243	-0.058	<.001	<.001	3	7
GBM	POLR2B →	-0.170	-0.049	<.001	<.001	3	7
UCEC	CBR1 →	+0.627	+0.048	<.001	<.001	3	7
UCEC	ME1 →	+0.841	+0.045	<.001	.002	3	7
GBM	PRPF8 →	-0.210	-0.045	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033559 vs AKR1C3 — UCEC

Explore this scatter interactively →