Unsaturated fatty acid metabolic process

Across TCGA cell cohorts, RNA activity of the Unsaturated fatty acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PAM, SH3BGR, and PPARD, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Unsaturated fatty acid metabolic process activity versus PAM in STOMACH (Pearson r = -0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PAM →	-2.001	-0.344	.001	.006	3	5
LUNG_NSCLC_LUAD	SH3BGR →	+0.516	+0.200	.009	.003	3	5
PANCREAS	PPARD →	-0.958	-0.377	.004	.005	3	5
BREAST	GUCD1 →	+0.490	+0.172	.009	.001	3	4
OVARY	MAPK8IP3 →	+1.427	+0.206	.001	.009	3	4
BLOOD_Lymphoma	SLAMF6 →	+3.889	+0.267	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033559 vs PAM — STOMACH

Explore this scatter interactively →