Multicellular organismal response to stress

Across TCGA patient cohorts, RNA activity of the Multicellular organismal response to stress pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WDR5, LYN, and RHBDF2_S385, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Multicellular organismal response to stress activity versus WDR5 in OV (Pearson r = -0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	WDR5 →	-0.221	-0.025	.002	.009	3	5
LUAD	LYN →	+0.260	+0.033	.001	<.001	3	5
LUAD	RHBDF2_S385 →	+0.396	+0.030	<.001	<.001	3	4
PDAC	RIF1_S782 →	+0.618	+0.021	.006	.006	3	4
CCRCC	SAP130 →	-0.137	-0.025	.002	.004	3	4
PDAC	SEPTIN2_S218 →	-0.396	-0.023	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033555 vs WDR5 — OV

Explore this scatter interactively →