Multicellular organismal response to stress

Across TCGA patient cohorts, RNA activity of the Multicellular organismal response to stress pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VRK1, CDCA3, and FAM72A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Multicellular organismal response to stress activity versus VRK1 in LSCC (Pearson r = -0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	VRK1 →	-0.592	-0.194	.002	.008	3	4
OV	CDCA3 →	-0.874	-0.157	<.001	.002	3	4
LSCC	FAM72A →	-0.466	-0.266	.005	.003	3	4
COAD	CSE1L →	-0.437	-0.146	.007	.002	3	4
LSCC	XPO1 →	-0.435	-0.191	.005	.005	3	4
LSCC	RANBP1 →	-0.678	-0.278	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033555 vs VRK1 — LSCC

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