Multicellular organismal response to stress

Across TCGA cell cohorts, RNA activity of the Multicellular organismal response to stress pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBL, MDK, and MPP2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Multicellular organismal response to stress activity versus FBL in LUNG_NSCLC_LUSC (Pearson r = -0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	FBL →	-0.953	-0.101	.006	.008	3	8
SKIN	MDK →	+2.601	+0.064	.001	.009	2	9
UPPER_AERODIGESTIVE_TRACT	MPP2 →	-1.464	-0.087	.001	.001	3	8
BREAST	PPM1G →	-0.600	-0.089	<.001	<.001	3	8
BLOOD_Lymphoma	LGALS3 →	+2.931	+0.091	<.001	<.001	3	8
LUNG_NSCLC_LUSC	EME1 →	-0.986	-0.079	.009	.004	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033555 vs FBL — LUNG_NSCLC_LUSC

Explore this scatter interactively →