Fatty acid beta-oxidation using acyl-CoA oxidase

Across TCGA patient cohorts, RNA activity of the Fatty acid beta-oxidation using acyl-CoA oxidase pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DECR2, BDH2, and ATP9A, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fatty acid beta-oxidation using acyl-CoA oxidase activity versus DECR2 in BRCA (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DECR2 →	+0.643	+0.066	<.001	<.001	3	8
BRCA	BDH2 →	+0.421	+0.047	<.001	<.001	3	7
PDAC	ATP9A →	+0.416	+0.041	<.001	.001	3	6
LUAD	HSPA13 →	-0.336	-0.047	<.001	<.001	3	6
CCRCC	ANK3_S959 →	+0.760	+0.058	<.001	.001	3	6
BRCA	JPT1 →	-0.391	-0.050	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033540 vs DECR2 — BRCA

Explore this scatter interactively →