Fatty acid beta-oxidation using acyl-CoA oxidase

Across TCGA patient cohorts, RNA activity of the Fatty acid beta-oxidation using acyl-CoA oxidase pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACOX2, FMN1, and SOX12, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fatty acid beta-oxidation using acyl-CoA oxidase activity versus ACOX2 in GBM (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ACOX2 →	+0.786	+0.158	<.001	<.001	3	5
BRCA	FMN1 →	+0.491	+0.138	.001	<.001	3	5
GBM	SOX12 →	-0.536	-0.135	.001	.004	3	4
GBM	BLM →	-0.895	-0.188	<.001	<.001	3	4
GBM	EIF4G3 →	-0.316	-0.170	<.001	.001	3	4
OV	SDC4 →	+0.684	+0.172	.001	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033540 vs ACOX2 — GBM

Explore this scatter interactively →