Fatty acid beta-oxidation using acyl-CoA oxidase

Across TCGA patient cohorts, RNA activity of the Fatty acid beta-oxidation using acyl-CoA oxidase pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ACOX2, SCP2, and NFIL3_S286, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fatty acid beta-oxidation using acyl-CoA oxidase activity versus ACOX2 in BRCA (Pearson r = 0.54).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ACOX2 →	+0.737	+0.307	<.001	<.001	3	5
OV	SCP2 →	+0.676	+0.177	.001	.002	3	4
OV	NFIL3_S286 →	-1.526	-0.363	<.001	<.001	3	4
COAD	U2SURP_T919 →	-0.890	-0.121	<.001	<.001	3	4
COAD	BUD13_S248 →	-0.963	-0.169	<.001	<.001	3	4
LSCC	DEK_S243 →	-0.494	-0.169	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033540 vs ACOX2 — BRCA

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