Fatty acid beta-oxidation using acyl-CoA oxidase

Across TCGA cell cohorts, RNA activity of the Fatty acid beta-oxidation using acyl-CoA oxidase pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NEK11, PHF11, and SQOR, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NEK11 grouped by Fatty acid beta-oxidation using acyl-CoA oxidase-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	NEK11 →	-0.947	-1.473	.006	.001	3	4
SOFT_TISSUE	PHF11 →	-1.792	-1.063	.002	.005	3	4
LUNG_SCLC	SQOR →	-2.163	-1.368	.002	.002	3	3
SOFT_TISSUE	ARR3 →	-0.166	-1.295	.001	.001	3	3
BREAST	MFSD10 →	-0.816	-0.756	.005	.004	3	3
SKIN	NTPCR →	+0.721	+1.389	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NEK11 by Fatty acid beta-oxidation using acyl-CoA oxidase activity — SOFT_TISSUE

Explore this box plot interactively →